How are orthologs and paralogs defined?


The VectorBase putative orthologs and paralogs are determined using the Ensembl homology prediction pipeline. Drosophila melanogaster is included in these predictions.

Broadly speaking, this means that after an all-versus-all BLAST step, genes are clustered, and then aligned. Phylogenetic trees are inferred from the multiple sequence alignments, from which homologs are determined. See the Ensembl documentation page for further details.